Regina H Silva Selected Research

Reserpine (Serpasil)

11/2022	Aging accentuates decrease in tyrosine hydroxylase immunoreactivity associated with the increase in the motor impairment in a model of reserpine-induced parkinsonism.
1/2022	Neuroinflammation in early, late and recovery stages in a progressive parkinsonism model in rats.
1/2022	Testosterone propionate improves motor alterations and dopaminergic damage in the reserpine-induced progressive model of Parkinson's disease.
1/2021	Nociception alterations precede motor symptoms in a progressive model of parkinsonism induced by reserpine in middle-aged rats.
1/2021	Female Rats Are Resistant to Cognitive, Motor and Dopaminergic Deficits in the Reserpine-Induced Progressive Model of Parkinson's Disease.
1/2021	Balance alterations and reduction of pedunculopontine cholinergic neurons in early stages of parkinsonism in middle-aged rats.
1/2021	Changes in the mesocorticolimbic pathway after low dose reserpine-treatment in Wistar and Spontaneously Hypertensive Rats (SHR): Implications for cognitive deficits in a progressive animal model for Parkinson's disease.
1/2019	Serotonergic dysfunction in a model of parkinsonism induced by reserpine.
1/2019	Sex differences in the progressive model of parkinsonism induced by reserpine in rats.
1/2018	Carvacrol prevents impairments in motor and neurochemical parameters in a model of progressive parkinsonism induced by reserpine.

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Regina H Silva Research Topics

Disease

14	Parkinson Disease (Parkinson's Disease) 10/2022 - 08/2008
10	Parkinsonian Disorders (Parkinsonism) 11/2022 - 09/2013
9	Catalepsy 10/2022 - 05/2012
6	Memory Disorders (Memory Loss) 12/2022 - 05/2002
4	Dyskinesias (Dyskinesia) 01/2017 - 05/2002
3	Tardive Dyskinesia 01/2016 - 05/2002
2	Sleep Deprivation 04/2006 - 11/2004
1	Mental Disorders (Mental Disorder) 12/2022
1	Inflammation (Inflammations) 10/2022
1	Pain (Aches) 10/2022
1	Weight Loss (Weight Reduction) 01/2022
1	Neuroinflammatory Diseases 01/2022
1	Body Weight (Weight, Body) 01/2019
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018
1	Movement Disorders (Movement Disorder) 01/2018
1	Genetic Predisposition to Disease (Genetic Predisposition) 01/2017
1	Cognitive Dysfunction 01/2016
1	Mood Disorders (Mood Disorder) 07/2015
1	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 04/2012
1	Amnesia (Dissociative Amnesia) 07/2006

Drug/Important Bio-Agent (IBA)

21	Reserpine (Serpasil)FDA Link 11/2022 - 05/2002
5	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 11/2022 - 09/2013
3	Dopamine (Intropin)FDA LinkGeneric 01/2022 - 01/2018
3	Anti-Anxiety Agents (Anxiolytics)IBA 02/2019 - 11/2004
3	Valproic Acid (Depakote)FDA LinkGeneric 05/2005 - 06/2003
3	gamma-Aminobutyric Acid (GABA)IBA 05/2005 - 06/2003
2	Volatile Oils (Essential Oils)IBA 10/2022 - 02/2019
2	CyclodextrinsIBA 10/2022 - 02/2019
2	SynucleinsIBA 10/2022 - 01/2017
2	Neuroprotective AgentsIBA 10/2022 - 01/2017
2	Ethanol (Ethyl Alcohol)IBA 01/2022 - 04/2006
2	CannabidiolIBA 01/2018 - 01/2016
2	Levodopa (L Dopa)FDA LinkGeneric 01/2016 - 07/2015
2	Therapeutic UsesIBA 05/2005 - 12/2004
2	Topiramate (Topamax)FDA LinkGeneric 05/2005 - 12/2004
1	Harmine (Telepathine)IBA 12/2022
1	Hallucinogens (Psychedelics)IBA 12/2022
1	AntioxidantsIBA 10/2022
1	Proteins (Proteins, Gene)FDA Link 10/2022
1	Testosterone Propionate FDA Link 01/2022
1	Estrogens (Estrogen)FDA Link 01/2021
1	Membrane LipidsIBA 02/2019
1	PeroxidesIBA 02/2019
1	Serotonin (5 Hydroxytryptamine)IBA 01/2019
1	carvacrolIBA 01/2018
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2017
1	alpha-SynucleinIBA 01/2017
1	Dopamine Agonists (Dopamine Agonist)IBA 07/2015
1	Antidepressive Agents (Antidepressants)IBA 04/2012
1	Scopolamine (Hyoscine)FDA Link 07/2006
1	PhosphatidylserinesIBA 07/2006
1	gaboxadol (THIP)IBA 05/2005
1	Diazepam (Valium)FDA LinkGeneric 05/2005
1	Baclofen FDA LinkGeneric 05/2005
1	Anticonvulsants (Antiepileptic Drugs)IBA 12/2004
1	SolutionsIBA 12/2004
1	Chlordiazepoxide (Elenium)FDA LinkGeneric 11/2004
1	Clonidine (ST 155)FDA LinkGeneric 11/2004

Therapy/Procedure

2	Injections 01/2021 - 01/2017
1	Treatment Delay 10/2022
1	Traditional Medicine (Folk Remedies) 10/2022
1	Subcutaneous Injections 01/2019
1	Drug Therapy (Chemotherapy) 01/2016